Merriam-Webster's Advanced Learner's Dictionary:
Mrs.
Mrs. US or Brit Mrs /ˈmɪsəz/ noun
1 a
- used as a title for a married woman
• Mrs. Smith
• Mrs. Jane Smith
• Mrs. Robert Smith [=the wife of Robert Smith]
- compare miss, ms.
b
- used as a title when speaking to a married woman who holds an honored position or office
• “It's an honor to meet you, Mrs. [=(more commonly) Madam] President/Chairman.”
2 a
- used as part of a title for a married woman who has won a contest
• Mrs. America
b
- used to refer to a married woman who is very successful and famous for a particular activity (such as a sport) or who has a particular quality
• She has come to be known as Mrs. Golf.
• He thinks his wife is Mrs. Wonderful. [=he thinks his wife is wonderful]